Among shellfish, shrimp is most involved in allergic reactions, as it contains tropomyosin. Shellfish, including crustaceans and molluscs, cause the most food allergies in both children and adults worldwide. The prevalence and types of food allergy vary according to age, local diet, and genes, and are triggered by various allergens sources, such as milk, eggs, peanuts, fish, and shellfish 11, 12. Food allergens can induce symptoms, such as rhinitis, urticaria, and anaphylaxis in patients 10. In addition to allergies from HDMs, food allergies have also become an increasingly troublesome issue over the last few decades. With a high homology to tropomyosin in seafood, Der p 10 has been described as a prominent challenger for severe systemic anaphylaxis 8, 9. pteronyssinus as they show cross-reactivity to allergens in invertebrates and seafood 7. In this study we have focussed on group 10 allergen of D. pteronyssinus are identified as major allergens and have been well studied 5, 6. More than 20 IgE-binding allergenic components of D. In the tropical and subtropical zones, the major indoor allergens are HDMs, such as Dermatophagoides pteronyssinus ( D. Increasing evidence demonstrates that the sensitization to indoor allergens is a causative factor for the development of airway hypersensitivity 1, 2. Overall, the level of mite or shrimp sIgE is influenced by alterations in age, and vegetarians are at risk of shrimp sensitization via cross-reactivity between shrimp and mite. The mite-Der p 10 not only displayed high cross-reactivity to the shrimp-Pen a 1 in all age groups and vegetarians but functioned as the major allergen to sensitize un-adults. Moreover, adults were more frequently sensitized to shrimp and mite at the same time compared with the un-adult or elderly groups. In contrast, shrimp-induced sIgE was higher in the adults and elderly patients. We found that HDMs induced higher sIgE than shrimp in un-adults. The sera with sIgE levels greater than 3.5 kUA/L were cross-reactivity examined. The serum specific-IgE (sIgE) level of HDMs and shrimp in 60 children/adolescence (un-adults), 30 adults, 30 elderly, and four vegetarian adults patients were measured. Therefore, we assessed the prevalence of shrimp or mite allergy among different age groups and vegetarians. Thus, vegetarians might be sensitized to shrimp through the inadvertent inhalation of HDMs. Due to the cross-reactivity between shellfish and HDMs, HDMs were considered as the primary sensitizer for shellfish allergy. The importance of cockroaches as a risk factor for sensitization and triggers of allergic symptoms in mainland of China needs to be further investigated.The sensitization to house dust mites (HDMs) and shrimps affects the development of hypersensitivity with an increase in age. However, a cross-inhibition study showed that only a small number of patients appear to have Bla g and/or Per a as primary sensitizing source. An IgE cross-inhibition study confirmed that Der p sensitization could cause false positive SPT reactions against cockroach.Ī relatively high prevalence of cockroach sensitivity was found in mainland of China. Of the SPT positive cockroach patients, 88% were also SPT positive to house dust mite (Dermatophagoides pteronyssinus, Der p). Patients had relatively low levels of cockroach SPT reactions, mainly class 1 or 2. The prevalence of positive cockroach SPT was higher in southern than in northern China, higher in adults than in children, and higher in males than in females. Totally 25.7% of patients were SPT positive to the American cockroach (Periplaneta Americana, Per a) and 18.7% SPT positive to the German cockroach (Blattella germanica, Bla g). Eighteen out of 1236 clinical sera from south China were selected to perform the cross-inhibition assay between house dust mites and cockroaches. Factors, including different regions of China, age, gender and the correlations between the American and German cockroaches and house dust mite Der p were investigated. The cockroach sensitization pattern was based on a skin prick test (SPT) obtained from a national multicenter prevalence study, in which 6304 patients from 25 allergy centers across China participated. The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients. Cockroaches are an important indoor allergen source causing allergic rhinitis and asthma.
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